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Hormone Replacement Therapy in Menopause

Natural menopause is the cessation of menstrual periods due to loss of ovarian function (follicular activity) and is confirmed when a woman has missed her periods for 12 consecutive months in the absence of other pathological or physiological causes. On average, it occurs at around age 51. Approximately 75 % of women experience hot flushes and night sweats at some point during perimenopause and approximately 25 % of women suffered from them for more than five years [1].

The impact of hot flushes on quality of life may be considerable and is often underestimated. Hot flushes and night sweats negatively affect quality of life for an estimated 20 – 25 % of women, due to physical discomfort and social embarrassment, with night sweats associated with sleep disruption. The sleep and mood disturbances that result from HF/NS can have a significant negative impact on overall quality of life [2].



1. American Congress of Obstetricians and Gynecologists (ACOG) 2011 Women’s Health stats & facts
2. Archer, et.al., CLIMACTERIC 2011;14:515–528